Jason, Harry, Sherman, and Kelly are old friends from high school whose lives haven't turned out the way they planned. A series of emergencies reunites the group and they find that, at the end of the day, that they've got each other in case of emergency.
Kelly's crazed cop boyfriend, Frank, catches Harry helping her move her things out of his place. Meanwhile Sherman's staff refuses to help him as his professional reputation spirals down, and Jason, now seriously smitten with Dr. Joanna, doggedly pursues her at the hospital.
Sherman and Harry sneak into an ashram to retrieve Sherman's ex wife, who currently lives with a phony billionaire guru. Kelly confesses to Harry that she accidentally killed her husband during a golf game. And Jason tries to convince Dr. Joanna's grandmother to accept medical treatment to save her life.
When Harry's boss reprimands him, he quits. Sherman starts wearing a disguise to avoid shoppers at the supermarket. Jason dodges a process server.
Harry begs Kelly not to tell Sherman and Jason that she's a hooker, while Sherman discovers that Jason's investment company has lost all of his money, and Dr. Joanna rejects Jason's advances.
Jason, on the verge of going to jail, can cut a deal if he rats on his Uncle Henry, who happens to be his mother Donna's favorite brother. Jason begs Harry to help him with his mother because she always favored Harry over him. Things quickly get hot when Donna's flirting with Harry leads to a deep, passionate kiss, leaving Harry more than a little flustered. And Kelly takes Sherman to a strip club in an attempt to get him over his wife.
Sherman struggles to maintain his diet. Dylan develops a crush on Kelly. Harry and Donna, Jason's mother, continue to sneak around. They decide to tell Jason, but he unfortunately walks in on them. Jason pretends to have a girlfriend to make Joanna jealous. It works.
Sherman convinces Kelly to help him kidnap his wife from an Ashram. Meanwhile, Harry talks to Jason about the fact that he's having sex with Jason's mother. Jason has proof that Dr. Joanna kissed him.
Kelly's strict parents show up for a surprise visit. Kelly creates a pretend life for herself, making her friends all play parts in order to please her parents. Kelly tells her parents she's married and Jason is her husband, but then her parents insist that she have a traditional Korean wedding.
When Harry's son, Dylan, is repeatedly harassed by a school bully, Kelly ignores Harry's passive solution by hiring two goons from the massage parlor to protect Dylan at school. And when Jason finally gets Dr. Joanna to go out with him, he finds himself mortified as all his possessions get repossessed right in front of her.
Harry and Sherman go to a spa to escape women, but Sherman spends the vacation looking for women. Meanwhile, Joanna gets a pain in her neck whenever Jason's name is mentioned, so she goes to see Kelly for a massage.
Harry tries to get his ex-wife and her boyfriend to marry so he can stop paying alimony. However he suddenly feels left out when his son prefers this new man over him. Meanwhile, Jason realizes his lawyer is Joanna's fiance, and Sherman tries to extend his fading fame by going into rehab.