Dennis is disappointed after joining an environmentalist group. Dee and Mac decide to raise a baby they find in a dumpster. Charlie tries to learn the truth about his paternity.
The Philadelphia Eagles hold open tryouts and Mac, Dennis and Dee use the event for their personal competition. Liam and Ryan's brother Doyle also wants to be an Eagle.
Barbara's sudden death causes a rift among her family and friends when Dee and Frank learn that they were left out of the will and Dennis inherits the mansion.
The McPoyle brothers and sister take the gang hostage at Paddy's. Meanwhile, Frank searches for his will in the airducts.
Dee discovers an overweight social outcast she new from high school is now a successful fashion designer.
A Korean restaurateur bumps Paddy's from the coveted pub crawl, so the gang must fight to get it back.
When the gang gets a good offer, they decide to sell Paddy's. However, this decision forces Dee and Charlie to find new jobs.
When Mac misses his chance at fame in the news he gets Frank and Charlie to help him create a public access newscast. Dennis and Dee try to make it in the club scene.
Dee gets involved with a famous local rapper whose success inspires the gang to start their own band.
After Mac starts behaving strangely, Frank becomes convinced he's the serial killer terrorizing young, blond Philadelphia women. Frank, aided by a chainsaw and a skeptical Charlie, sets out to find evidence implicating Mac in the murders, but the whole gang is shocked to discover that Mac's big secret is that he's dating a transsexual.
Dennis is mistaken for a registered sex offender, which bothers him more because the man is fat than because he's a sexual predator. Mac tries to bond with his ex-convict father.
When the gang finds themselves in debt to the mob after a misunderstanding over a set of speakers and a stash of cocaine, Frank convinces Dennis to allow him (Frank) to pimp him (Dennis) as a male escort.
To earn the $25,000 they need to pay back the mob for the drugs they stole, Dennis becomes a male escort and Charlie and Dee attempt to sell cocaine, but wind up becoming addicted to it. Mac, enamored with the mafia lifestyle, becomes a gofer for the gangsters. In the end, they make the money to pack back the mob by selling one of Ralph's possessions.
To get rid of the masturbating bum in the alley, Frank and Dennis buy an old cop car and pose as cops, and Dee and Mac become Guardian Angels.
When Charlie accidentally lists the bar as the prize in a dance contest, the gang must win it back. They start out as a unified front but quickly begin in-fighting and sabotaging each other. The winner is ultimately a homeless man hired by Frank.