After losing the million dollars he won in the World Poker Championship only a year ago, Lucky must pay back the parents of his deceased wife for her funeral costs without resorting to gambling.
Lucky must pay off his debt to Joey Legs, which forces him to continue to gamble, only a luckless doctor and her son with money problems complicate his goal.
Lucky tries to show Theresa he's serious about straightening out his life by getting a job selling meat, which brings him into some dangerous competition with a competing meat business.
Lucky continues to offer support to Theresa, who is working out problems with her husband and trying to avoid gambling, but conceals his own gambling from her.
Lucky develops a tell which could ruin his chances for victory at a big poker tournament. Meanwhile, Mutha and Vinny pretend to be expert card-counters in order to scam a mark.
Lucky uses his deceased wife Sarah's mantra to help him win big in Vegas on the anniversary of her suicide, but despite the success of his goal, he is still unable to fully cope with his personal loss.
When Vinny and Mutha are caught snatching coins at a casino, a detective views the incident as his chance to extort five thousand dollars from Lucky.
Lucky makes a deal with a famous actor to show him the ropes of pro gambling as his technical advisor.
After being accused of cheating, an innocent Lucky is banned from gambling at the casinos, prompting Vinny and Mutha to track down whoever has set him up. When all signs point to Amy as the culprit, she denies any involvement and vows to help their search.
Lucky honors the yearly tradition of deciding whether to stay in Vegas with a game of roulette, stating that if he ever hits his birthdate on the wheel, he'll leave. This year, however, he's hit the number.
Lucky and Theresa get into a squabble with one another, leading to a pivotal crossroads in their relationship, and Vinny and Mutha end up doing more harm than good when they try to patch things up.
Lucky is compelled to intervene on Danny's behalf during Danny's court case for charges of possession, which puts Danny in his company during a poker tournament. Meanwhile, Theresa starts gambling again after 57 days of staying clean.
Lucky decides he'll hang up gambling for good after he wins the million dollar tournament that sent his life on a rollercoaster ride downward, but acquiring the necessary funds proves to be complicated when Theresa refuses to help feed his gambling habit.