A small-change crook tries to right the wrongs he committed in his life when he learns about karma and starts with a classmate he teased back in the day. He learns that the classmate is gay, fights through his initial discomfort and helps him get the courage to approach another man.
Earl finds it harder than he thought to quit smoking. Earl also must contend with a man who went to jail for a robbery he committed. Having found Jesus, he is quick to forgive.
When Earl goes to pay back a bookie for a game he rigged, he realizes that he has to add his brother Randy to his list, having enlisted him to rig the game and throw away his chance at a touchdown.
Earl has to make amends to an ex he broke things off with by faking his own death. When he lies and says that it was him, he ends up back in the relationship.
Earl teaches a classroom of non-English speakers to make up for having made fun of people with accents. Ralph, Earl's old acquaintance, tries to take the lottery winnings away from Earl.
Earl tries to make amends to Joy for breaking her figurine by helping a woman and her daughter win a Mother/Daughter beauty pageant. Joy asks that he give her a hot tub if he can't replace it. Earl learns that the contest daughter wants to escape her mother's desire to have her compete.
Earl's attempt to make amends with a golfer he took beers from leads to more work than originally planned as the golf-game-fixing Earl facilitated ruined the man's life. Earl's ever-expanding mission keeps him from taking Randy to the fair.
Joy invites Randy but not Earl to her wedding which she happens to schedule on his birthday. Earl gets drunk, ruins the wedding and vows to make it up to her. As he pulls her new wedding together, they fall prey to a moment of passion. Earl then has to tell Crabman about the encounter.
Earl tries to set things right by his father by attempting to get him elected as Mayor.
Earl tries to make up for years of poor Christmas gifts to Joy. Randy tries to win a car for Joy by keeping his hand on it after Earl is immediately kicked out of the competition. Joy pretends to still be married to Earl to appease her allegedly racist parents, but as it turns out, Joy's parents also get caught in lies of their own.
Earl worries that his ranch barn burning youth may have led to Joy's kids rejection from that same ranch for troubled youth.
Earl learns that a stolen wallet cost a couple their honeymoon and tries to make amends. Earl tries to figure out why his mean boss has done so well for himself, considering karma.
Earl tries to make amends for a hot dog cart he stole with Ralph and, in doing so, reunites the gang for a caper against a hot dog corporation.
Earl works to provide an arrested friend with a good day to make up for one he ruined in the past. Randy seeks employment.
Earl tries to make amends for having stolen gas from a stranger's car. He returns the gas, but learns that the man had been trying to kill himself with car exhaust. Returning the gas causes the man to start attempting suicide again. Joy makes Darnell throw out his adult magazines.
En route to return a laptop computer, Earl knocks down a bus stop sign, adds it to his list and promises that he'll be back to fix it the next day. When it turns out the laptop owner is a brainy and beautiful professor who takes a shine to Earl, he starts putting off the bus stop repair and karma enacts its vengeance. While on campus, Randy pledges a fraternity.
Earl has a hard time making amends for not paying taxes when the government refuses his money. When Earl volunteers with some roadside criminals, he ends up on a bus to jail. In an attempt to get a trespassing ticket, Earl and Randy wind up trapped inside a dry water tower.
For her birthday gift, Earl's mother tries to get Earl to right the relationship with his father, which Earl decides must be done by retrieving Carl's old Mustang which he secretly lost in a race as a kid.
Earl tries to right the wrong of a stolen take-a-number dispenser, and Randy brings him back to a memory of 1999 when the two acquired it, and when Darnell explained the group's chances of Y2K survival.
Earl tries to make up for scaring a kid with ideas of the Boogeyman and learns in the process what impact the terrifying thought had on him.
In order to protect Joy, Earl finds himself in desperate need to take care of number forty-five on his list, "ditched Jessie to marry Joy." When Jessie, Earl's ex-girlfriend, returns to town hell bent on seeking revenge against Joy for causing Earl to leave her and knocking out her front teeth, Earl and Joy seek refuge in a lakeside retreat. Jessie, however, cleverly weasels the secret location out of Randy enabling her to continue her pursuit.
Number 127 on Earl's list, return the stolen badge. Years back, Earl stumbled across a police badge while stealing people's shoes at a bowling alley, but when he is reunited with the badge while hanging out near a storm drain, Earl decides to find the police officer the badge belonged to.
Earl attempts to cross out number 147 on his list "Shot Gwen Waters with a BB Gun". To make things right he must reunite Gwen with her estranged father which Earl finds increasingly difficult.
Earl decides to cross off "Number 1" on his karma list, “Stole ten dollars from a guy at the Camden Market.” To his dismay, Earl finds out that he owes much more than ten dollars, in fact he must surrender all his lotto winnings. Earl now ponders when karma is going to help him with his misfortunes.