A brilliant New York homicide detective has a secret--he's immortal. In response to a heroic action, John Amsterdam will not age a day until he finds "the one.
Amsterdam and Eva investigate the suspicious death of a student at a prestigious New York City private school, which leads to the revelation of a twisted "affair." One of Amsterdam's biggest secrets is revealed, and we flashback to 1941 when the secret began.
A homeless Gulf War veteran confesses to the grisly murder of a controversial psychiatrist, but Amsterdam is skeptical. While reviewing the psychiatrist's soon-to-be published book, Amsterdam contemplates the reliability of memories and the reasons people bury them.
The brutal rape and murder of a nun, and similar attack on a photographer's assistant who escapes death, leads Amsterdam to remember similar crimes he witnessed in the 1800s, when he was a coachman for a wealthy landowner. Meanwhile, Amsterdam and Sara get better acquainted.
John and Eva investigate the death of a homeless man, whose best friend believes that his overdose was actually a homicide. They uncover a mysterious connection, between the new homeless shelter and an expensive guitar the dead homeless man kept in his locker. Meanwhile, John remembers when he struggled with addictions and entered a 12-step program back in 1964, after passing out drunk one too many times and ending up in a psych ward.
When police find a bullet-ridden body in an apartment in Chinatown, John and Eva are called to investigate. The deceased young man's striking similarity to Roosevelt, a lost son of John's from the early 1900s, prompts him to take a personal stance on the case.
John becomes fixated on granting the dying wish of his first partner, Andy, who is slowly wasting away from leukemia caused by a bullet lodged in his heart.
Still recovering from his recent gunshot wound, John and Eva investigate what looks to be the drowning death of a young woman. The victim's death may be related to a string of robberies of wealthy men linked to a dating service.