Christian and Sean, who are settling into their new location on Rodeo Drive in Beverly Hills, enlist the help of a Hollywood publicist (Lauren Hutton) to get their practice off the ground.
Christian, jealous over the attention Sean is getting from the TV show, does a nude photo shoot to increase his public profile. Christian's jealousy even causes him to try to steal Sean's new girlfriend Kate, the female star of the TV show he's working for, after Sean performs a body lift on her to the remove excess skin from her previous gastric bypass surgery.
After Sean's new girlfriend Kate loses control of her bowels in the hot tub, she reveals that she sometimes binges and takes laxatives. Julia finds herself attracted to Christian, so her lesbian partner Olivia encourages her to have sex with Christian (which she does) to get him out of her system.
Eden teaches Annie the finer points of eating disorders and oral sex, the latter of which gets Annie expelled from school. Christian treats a nun and later has a religious awakening of his own.
Sean treats a patient who attends interracial swinger parties, where young black men and older white married couples indulge their fantasies. When Kate tells Sean that that scenario interests her, they attend one of the parties together, but Sean freaks out and he and Kate have a big fight.
Jealous over Sean's new-found fame, Christian convinces Sean to tape a reality show based on their careers as plastic surgeons. Olivia and Liz share a kiss, which threatens Julia and Olivia's relationship.
After Julia and Olivia are carjacked, Julia begins to crave the safety and protection she feels in Christian's presence and questions her decision to be with Olivia.
Sean discovers that Christian and Julia are sleeping together. Matt, in the hospital after a meth-cooking accident leaves him with severe burns over much of his body, bonds with his rehabilitation counselor, who herself was badly disfigured in an explosion. Eden gives Julia a drugged fruitcake. Christian and Julia go to see Kimber and Ram, who refuse to let Matt see the baby and reveal their plan to get married and have Ram legally adopt her.
When Rachel asks Sean to perform facial reconstructive surgery on her, he wonders if she's falling in love with Matt. Dawn Budge returns to McNamara/Troy after an accident with a biker at the gay pride parade leaves her with facial injuries. Sean hires Gina as the receptionist to annoy Christian, and the two docs come to blows over Julia.
Sean's role on Hearts & Scalpels is expanded after he takes on an agent. Julia, whose illness remains undiagnosed, becomes convinced that Christian has given her AIDS, but her test comes back negative. Gina seduces Christian and then tells Julia all about it, after which Christian serves Gina with a restraining order. But Gina convinces him to have one last fling on a roof deck, during which she accidentally falls to her death.
Christian attempts to cope in the aftermath of Gina's death. Sean's agent Colleen feels threatened when another talent agency shows an interest in Sean's acting career.
When Eden goes to Sean for help after going into business with Kimber and Ram, Sean buys Eden out of her contract by performing surgery on a number of Ram's porn stars.
Matt starts a sexual relationship with Christian's new patient, Emme, before Emme reveals that she thinks Christian is her father (which would make Matt her brother).
Julia is in a coma after being shot by Eden, who had been trying to kill her by putting mercury in her food. Eden confesses to Olivia after learning that Julia has awakened from the coma, but when it's revealed that Julia has amnesia, Olivia keeps her daughter's secret.