Jane Vasco is a DEA agent who gets roped into a secret group within the government that tracks down a group of people called Neuros: people with superhuman powers.
Jane and the team believe a group of undead is helping a Neuro with an assassination attempt against the President. Now they must investigate without being discovered by the federal government. But when they learn that the Neuro is just a kid who has the power to control the dead with no intention of harming the President, their strategy changes and Jane is asked to sacrifice her body in order for them to neutralize the Neuro.
When specialists from a variety of professions begin to lose their specific career memory, Jane and the team search for a Neuro apparently bent on sucking memories.
Jane and the team look for a Neuro whose power is premonition. He tries to warn Jane via a DVD that in three days he will kill three members of her team before she kills him.
An FBI safehouse for people in witness protection begins to drive its inhabitants insane. The team investigates and discovers that the spirit of a deceased man has been trapped within its walls.
Jane and the team track down a Neuro who needs to transfer her nightmares to other people in order to function. Problem is, her nightmare drives those other people insane. Meanwhile, Carpenter and Andre make an unsettling discovery about Jane and the nature of her Neuro powers.
The team hunts down a Neuro adept at creating elaborate hallucinations for his victims in order to lead them into their deaths. His purpose for killing is to avenge the death of his daughter, who was killed by a criminal in witness protection. He wants everyone involved in the protection program, as well as those criminals it protected to die for their deeds and only Jane and her healing power stands in his way.
Jane deals with a shape-shifting Neuro who has imprisoned her in a mental hospital.
Jane and the team try to save one of their own, after Connor is accused of murdering a woman and fabricating a serial arsonist to cover his tracks. It turns out the deceased woman's husband killed her and it was Jane's bosses who set up Connor to take the fall.
Jane and Maureen go undercover to find out why a young woman has mysteriously aged dozens of years overnight.
Connor suffers a series of unfortunate events, believing it to be coincidental. However, he learns that members of his former police squad have died of strange causes.
Jane and Connor go undercover in a small town, posed as a married couple, after a federal agent's disappearance prompts an investigation.
An investigation is started after Neuros begin to die before the team can apprehend them. A Neuro takes matters into his own hands when his friends abuse the powers he gave them.
Howie is a magician who can miraculously perform the impossible, which prompts Riley to begin an investigation into possible Neuro activity. He goes alone, and he is captured.
Jane secretly visits a faith healer to try and "heal" herself from her abnormal powers. The faith healer seems to have some inexplicable abilities of his own, leading Jane to wonder if he is sabotaging the team's effort to catch a Neuro.
After a rough day at work, Jane comes home to find that her boyfriend has no idea who she is. She begins learning that the government is destroying all evidence of the Neuro project's existence. She runs around desperately to save her memories and stay alive. Thankfully, when all seems lost, Jane wakes up from her very bad dream.
A Neuro gets the team stuck in a timeloop, causing them to relive the same day repeatedly. Meanwhile, the Neuro who caused the timeloop tries to finish an assassination.
While searching for a Neuro who escaped the team, Jane discovers the disturbing truth about her abilities.
The team heads to Hungary after a half-dozen Neuros have escaped out of NICO, the overseas internment center. They try and figure out why and how they escaped.
The residents of a small village are plagued by an invisible and mysterious presence which is attacking and murdering them.
Andre encounters a Neuro from his past that was chipped. He learns that she has regained her abilities, and that she has a grudge.
An emergency at NICO results in a prison riot where retribution-seeking Neuro inmates can shoot laser beams from their eyeballs. After Jane is hypnotized into siding with them, her team must figure out a way to snap her out of it.