With their parents away at a Bruce Springsteen concert, the five Chase children decide to throw a party.
Flu spreads throughout the family, starting with Penny who starts off a quarantine area in the basement.
Bob worries about Patton when he joins the cheerleading squad, but his concern melts away when he learns Patton could earn a college scholarship. The only thing standing in Patton's way is his constant arousal while surrounded by hot cheerleaders. Penny tries to help Paige embrace the dark side of things.
Bob gets his children to do his bidding around the house when he wins a cell phone and they all want a shot at using it.
Bob tries to fend off a rival quintuplet family up for a car commercial. When Parker opts out, Paige's boyfriend fills in as the fifth quintuplet. Penny rebels by dating a quint from the other side of the battle lines.
Bob and Carol decide that it's time for the quints to pay their own way and make them get jobs. Paige and Patton battle on the shoe selling front. Parker deals with fast food and acne. Bob and Carol try to figure out what to do with the extra money they'll have by saving on allowances.
The school's swing-themed homecoming dance affects the quints as they shuffle to find dates and Paige announces her homecoming queen candidacy. Parker is threatened by girl's brother into asking her to the dance. Penny's gay date abandons her for Pearce.
The quintuplets take over the school's production of Romeo and Juliet. Patton as Romeo gets to kiss Parker's girlfriend who has been holding out that affection from Parker. Bob convinces Carol to go to the neighbors for dinner.
A visit from a friend causes romantic tension when Parker starts to feel a connection and the girl feels for Pearce. Patton tries to get a glimpse of his sister's slumber party.
Pearce, Parker and Alayna team up on a science project and create electricity. Penny uses Paige as the unknowing subject of her own science experiment. A beautiful girl takes an active interest in Patton, baffling all around.
The Chases go to a multiples convention. Patton tries to work his charms on twin sisters even as Penny and Paige check out twin brothers. Carol and Bob take on a mentoring role for parents of another set of quintuplets.
Bob and the quints perform at their school's battle of the bands. Bob takes over Parker's band for a shot at reliving a glory he never knew. Patton coaches his sister and her friends for their performance. Pearce performs on an obscure instrument.
Bob tries to get leverage on a client by having Patton pose as a 10 year old to befriend the client's son, but Patton then tries to score with the babysitter. Parker and Pearce try to split time with Alayna. Penny shows up at Paige's work and tries to ruin things in an effort to get Paige to repay a debt.
Parker, Patton and Pearce sample college life in the form of a fraternity party which quickly turns into a road trip. Carol learns a bit too much from Penny and Paige when she grants the girls amnesty for any truth they reveal to her.
Patton finds himself attracted to a new teacher, but his competition comes in the form of Coach Scales, who in turn takes it out on Parker. Bob tries to help Pierce with a paper, but ends up writing it himself.
Bob's visiting brother lands Bob in hot water during his Thanksgiving stay.
Parker doesn't like it when his mother bonds with his date. Penny tries to get Paige to see the real reason why she's going out with a guy -- money. Patton enlists Pearce's help when a girl's dog runs interference.
The Chase children decide they'd like the actual articles for Christmas and not just pictures. Bob and Carol attempt to win money for gifts in Atlantic City. Patton and Parker participate in a nativity and each tries to woo the girl playing Mary.
A documentary crew invades the house for a TV special aimed at finding out how the family has changed since their last visit.
Pearce asks Parker to help keep him from becoming a stalker when he finds it difficult to be apart from his girlfriend Alayna.
Carol feels left out when Bob, Paige and Penny get to share the events surrounding the death of her Great Aunt because she forced Bob to go on a visit in her place. Pearce has a hard time getting past first base with Alayna. Patton finds a scam turned on him when he takes on a female partner.
When Carol bans Patton from female contact, Patton thinks he's escaped girls by joining the wrestling team, but then he's matched up to face one. Carol tells Paige that she has to lose some of her rapidly expanding wardrobe. Penny and Parker get busted by a traffic camera.