When they find young war veteran Greg Tanner murdered in a Hudson University parking garage, Detectives Cyrus Lupo and Kevin Bernard connect the murder to law professor Kevin Franklin, an attorney who formerly worked for the Department of Justice.
After CSU investigator Daisy Chao is found murdered in her apartment, Detectives Cyrus Lupo and Kevin Bernard suspect her fiancé Jim Anderson may not be telling the whole truth about his involvement with the murder.
When an aspiring musician is found dead behind a trash can, Detectives Cyrus Lupo and Kevin Bernard find a bag full of cash leading them to a slew of suspects including Don Sorenson.
When Larry Johnson arrives home from picking up his adopted, physically disabled children from school, he discovers his wife's dead body on the floor of their home.
When Dr. Walter Benning is killed in church, Detectives Cyrus Lupo and Kevin Bernard arrive at the scene and are informed a white male who was seen fleeing in a dark sedan.
When Sid Maxwell, owner of a fashion company is found dead, Detectives Cyrus Lupo and Kevin Bernard assume asphyxia. But when fashion photographer Terry Clark leads the detectives to an alarming discovery of Maxwell's true identity, they uncover a suspicious website with threatening web posts.
When a young woman is found dead in her apartment, a few tell-tale signs quickly lead Detectives Cyrus Lupo and Kevin Bernard to believe that the killer was not after her wealth. After finding suitcases filled with money and drugs in one of the victim's apartments, the detectives watch a security video from her lobby. The video exposes two potential suspects leading the detectives to a drug cartel.
A deadly drunk-driving car accident brings Detectives Cyrus Lupo and Kevin Bernard to the scene when a suspicious nasal spray is found. After the medical examiner realizes the nasal spray is a powerful anesthetic that could easily disorient its user, the detectives become suspicious of the victim's boss, Zach Marshall.
After a key witness for a murder trial is found dead outside her hotel room, Detectives Cyrus Lupo and Kevin Bernard become involved in a spiraling case that unravels into an intricate conspiracy, leaving additional witnesses' lives in danger and Rubirosa in the crossfire. Black market dealings, affairs and drug cartels intertwine to expose the risk of taking the stand as a witness when corrupt officials control the court.