Nate and Brenda prepare for their impending nuptials while Ruth dreads George's return from the hospital and David and Keith discuss parenting options.
Nate has to handle the funeral of a high school friend; Brenda finds out that her new internship is harder than she had imagined; Ruth receives help from George's daughter and David asks Claire to donate some eggs for a surrogate mother.
Visions of an early trauma plague George. Claire is enthralled by Billy's new lust for life and Brenda forges a bond with her new supervisor.
Nate's reaction to Brenda's surprising news is not what she expected. Claire becomes increasingly horrified with Billy's descent into madness and David and Keith make an offer to the surrogate.
David and Keith await good news from Mary. Vanessa is irate after Rico blames Julio's trouble at school on their divorce and Nat and Brenda disagree on the amount of information to give Maya concerning Lisa.
Aunt Sarah arrives at the funeral home to arrange for the funeral of her friend, who had deflowered Nate. Claire signs up with a temp agency while waiting for a grant to come through. David and Keith butt heads over the best parenting methods for their new foster charges.
Ruth tries to fill her life with diversions after leaving George. Keith and David continue to struggle with parenting and Brenda and Nate receive some blood test results that may affect their unborn child.
The funeral of a young Latina raises questions about the future of the funeral home.
The family gather at the hospital as Nate slips into a coma following his collapse.
The whole family copes with Nate's death in a variety of ways. Keith makes an embarassing discovery and Rico and Vanessa take steps to protect their future.
When David's unpredictable behavior continues, Keith makes a hard decision to protect the boys. Billy arrives to take care of Brenda and George tries to help Ruth care for Maya.
In the series finale, the Fishers begin to find peace in the wake of Nate's death. Federico and Vanessa celebrate a new business and Claire leaves California for New York.