Ben and Lu take HIV tests before they take their relationship to the next level, but Ben learns that he's positive. Ben's ex-wife tries to warn Lu away from him. Eventually, Ben and Lu find out that his first blood sample was tampered with. Andy daughter has an emergency situation of her own when one of her friends stops breathing after trying to get high on cough syrup.
After being treated for fatigue, a pop star agrees to let a young patient sepnd the day with her, but then falls pray to the child's mother's molestation charges. Andy is approached by a woman who wants to rescue her husband's sperm when he is killed in a car crash.
The child produced by a rape learns of her origins only when she is in need of an organ transplant. Lu is presented with a problem when the formula that the clinic has been providing mothers is found to lack an essential vitamin.
Andy's vacation is disturbed when she learns that the resort town is a hotbead for cancer and that the residents are trying to keep that information private so as to not lose their tourist income.
Andy's visiting ex-husband is not keen on her relationship with Milo. A judge faces a loss of hearing due to misuse of prescription drugs. Accusations in the death of an elderly patient fall on Peter.
One of Andy's patients develops psychological problems in the wake of her breast cancer ordeal. Lu is faced with the question of whether or not to join Ben in a move to Miami.
Andy is disciplined when a patient submits a racism complaint. One of Lu's patients wants to opt for a faith healing over the surgery they require. Jonas asks Lu out.
Lu tends to two poisoned girls and learns that their poisoning came at the hands of a classmate they bully. Andy agrees to endorse a friend's heart health book and then is visited by her friend who appears to be having heart problems.
Lu finds a possible large donation for the clinic if she'll give some adult film actors physicals, but in the process discovers an actor with VD. Kayla's gunshot wound patient turns out to be a robber and murderer.
A gymnast turns to Lu for help in finding a donor liver for her ill sister. Andy and Kayla look into the past of a resident who has attempted suicide. Lana and Peter come to the aid of a visually impaired patient in helping to make her apartment more accomodating for her condition.
Andy treats a person who took a fall into a ravine which may not have been an accident. Peter takes care of a severe allergy sufferer. Lu's patient causes legal problems for Robert when it turns out she's a prostitute.
Lu assists a cleaned-up junkie in her custody battle, but it turns out that one of Andy's patients is the adoptive mother. Andy tries to aid a woman fighting off ovarian cancer.
Lu jumps to the conclusion that her son is the father when she discovers that one of his friend's is pregnant. Andy works with her daughter's school's cafeteria to battle the school's weight problems.
A couple attempts in vitro fertilization with Andy though they have less than noble intentions. Lu tries to land a girl with bipolar disorder a place at a mental health facility.
Andy comes face to face with the teen responsible for Milo's death. Jessie gets into a car accident after driving drunk. Lu tries to find the people who received organs from a person who turns out to have had rabies. Jonas comes under investigation for insider trading.
Lu treats a young girl whose only hope of surviving third-degree burns is a skin tranplant from her twin. Andy's missing cadaver leads to a black market.
Andy works to save the lives of a woman and her unborn child after a car accident endangers both. Jackson suggests that Andy take over the newly vacated position of Chief of Surgery. Lu takes on a drug company when it seems like one of her patients may be the stepping stone towards a cure for leukemia.
Andy takes on the case of a child having a heart attack. Lu deals with a child of her own when a surrogate couple refuse a baby because of its brain disorder.
Andy tries to help a woman live long enough to become a grandmother. Lu delivers the child while on Jonas' plane.
The Rittenhouse EMS team is introduced.
Andy removes implants from a beauty pageant contestant who tests positive for Lupus. Jonas asks Lu to meet his family. Lu tries to deal with the bureaucracy surrounding a group of pregnant illegal immigrants that arrive at Rittenhouse.
Jonas proposes even as Lu finds out that he might be moving his operations to Brazil. Andy is questioned about the manner of treatment in the clinic during her nomination for Surgeon General. Andy's staff toes the line to try to support her. Kayla and Peter have a hard time finding some private space for intimate activities. Andy is sworn in as the Surgeon General.