Melinda Gordon, a woman who can see and speak to earthbound spirits who have yet to cross to the other side, must help the spirit of a soldier who died in Vietnam and doesn't realize he is dead.
When a little boy is killed in a broken down car stuck on some train tracks, Melinda helps him console his mother and convince her that the accident was not her fault.
Melinda helps a teenager who has been sent to a psychiatric clinic because her deceased twin sister is haunting her.
A young woman attemps suicide after her fiancee's death and Melinda agrees to help the deceased fiancee talk the grieving woman out of another attempt.
Melinda discovers the ghosts of three young boys and a dog that perished in an orphanage fire in 1956 and must help them cross over before they are doomed to drift as earthbound spirits forever.
Melinda tries to help a dead teen find his birth mother. Andrea's successful brother visits.
Melinda meets the spirit of a young woman in the hospital and helps her to discover why she died during a routine medical procedure.
To stop the dangerous spirit of an ex-con from haunting Jim, Melinda must help the spirit make amends with his wife and son.
Melinda discovers spirit voices through electronic-voice phenomenon and must decipher the messages to reconcile a mother with her teenage son.
Melinda tries to assist a friend of hers who is being haunted by the spirit of her fiance's late wife.
Melinda is approached by the deceased mother of an amateur boxer to enlist her aid in brokering a peace between her husband and son, who have become estranged.
Melinda assists a dead comic who is haunting a comedy club, to receive closure in the wake of his tragic suicide.
Melinda's neighbor is haunted by an old man who suspects that the man killed his granddaughter.
The spirit of an artist who was executed for murder contacts Melinda in order to get his daughter money for his paintings.
Melinda's first ghost, an eight-year-old girl, reappears to seek help in locating her parents.
Melinda must use her talents to help rescue the brother of Andrea's friend, who went missing during a hike.
The spirit of a very angry young boy haunts his workaholic mother, who neglected him when he was alive.
Melinda assists the vengeful spirit of a magician in discovering the truth about his death.
The spirit of an African American man haunts the prosecutor- turned- judge that left out evidence that could helped convict a white co-worker that killed him in a fight in the 1970s. Melinda helps the spirit find justice before he crosses over.
As a result of a car accident Melinda's head injury leaves her ability to communicate with the dead in jeopardy.
Melinda is contacted by an airline pilot and a flight attendant that’s trying to warn her about something. When she finally realize that they're trying to warn her about plane that's going to crash right outside of town, it’s too late. She tries to warn the correct officials and transportation authorities but despite her efforts the plane crashes anyway killing hundreds, marking Melinda's biggest case yet.
Melinda is up against her biggest case, after a Jetliner crashed, and now has to help the hundreds of unfortunate passengers crossover. She also has to work with the crash investigators that want to know how she knew about the crash before it happened. She also learns that the "Wide Brim Man" is working against her.