In the fourth-season premiere, Betty settles into her new job as an associate editor at Mode but clashes with her ex-boyfriend Matt, who's now her boss, and tries to stay a step ahead of Marc, who feels slighted by her promotion. Meanwhile, Daniel struggles to cope with Molly's death and the loss of Betty as his assistant, and Justin has trouble fitting in at high school. Lynn Redgrave and Kristen Johnston guest star.
One of Hilda's customers (Adam Ferrara) helps Betty get scoop from a top designer, but when Marc plots against her, it leads to a confrontation at the restaurant where Ignacio works. Meanwhile, Daniel meets an exciting woman (Jamie-Lynn Sigler) at his support group, and Wilhelmina searches for Connor in the Caribbean.
Marc is assigned to be Betty's temporary assistant while she works on a story about New York's worst jobs; Hilda becomes a potential political liability to Archie's campaign; Natalie's group leader (Dylan Baker) takes an interest in Daniel. Lexie: Brooklyn Decker.
Betty feels left out when Daniel makes Natalie (Jamie-Lynn Sigler) his new assistant; Wilhelmina's fund-raiser for Tibetan orphans creates a dilemma for Matt; Claire's history with Cal is revealed to her son.
A teacher (Adam Rodriguez) at Justin's school sends Hilda and Betty swooning down memory lane; Daniel takes Amanda to a meeting of his support group; Marc points Justin in a new direction in his search for friends at school; Wilhelmina goes to extremes to help Nico.
When Daniel gives Bennett (Dylan Baker) and the Community of the Phoenix unprecedented access to the levers of power at Mode, Betty hatches a plan to shock him back to reality. Meanwhile, Wilhelmina uncharacteristically stops caring about her appearance, sending Marc on a quest to find out more about Nico's story. Natalie: Jamie-Lynn Sigler.
Love is in the air when a photo shoot takes the Mode staffers to resort in the Bahamas (where singer Shakira is a guest), but the job also creates friction between Wilhelmina and a rival editor (Christie Brinkley). Meanwhile, back in Queens, Hilda reconnects with an old flame (Adam Rodriguez). Matt Newton, whose sister Becki plays Amanda, also guest stars.
Ignacio's preparations for a holiday feast with his new girlfriend, who's Jewish, coincide with Hilda and Betty worrying that the Suarez family is about to have two new members. Meanwhile, Cal hires a movie mogul (Nadia Dajani) to replace Wilhelmina as Mode's creative director, and Amanda helps Claire search for the son she gave up for adoption.