The political drama earned Grammer a 2012 Best Actor Golden Globe Award for his portrayal of fictional Chicago Mayor Tom Kane, but the show is destined to be short-lived.
Executives at cable TV network Starz have decided not to renew the programme for a third season due to low ratings.
A statement from the studio reads: “After much deliberation, we have made the difficult decision to not proceed with Boss. We remain proud of this award-winning show, its exceptional cast and writers, and are grateful to Kelsey Grammer, (creator) Farhad Safinia and our (producing) partners at Lionsgate TV.”
Since his star turn in Frasier, which wrapped in 2004, Grammer has been struggling to reconnect with viewers on the small screen – Back to You and Hank were also axed after just a handful episodes.