Rumours the pair was in talks to star in their ninth collaboration surfaced earlier this year (10).
And, at a BAFTA’s A Life In Pictures question and answer session earlier this month (Dec10), the legendary filmmaker revealed they are set to start shooting The Irishman in 2011.
The film will focus on Frank ‘The Irishman’ Sheeran, a union official who turns mafia hitman.
Scorsese added that the screenplay will be penned by Gangs of New York writer Steve Zallian, according to Digital Spy.
Scorsese and De Niro have previously teamed up for a string of iconic movies, including Taxi Driver, Raging Bull and Goodfellas.