The series revolves around four female roommates at top New England university Essex College as they embark on a new chapter of their lives. Sprouse will play a junior named Nico on the show, which is being developed for U.S. streaming service HBO Max, reports Variety.
His last big TV role as a series regular was on The Suite Life on Deck, a Disney Channel spin-off of The Suite Life of Zack & Cody, which ended in 2011.
Sprouse has since appeared in a few films, including the recent After We Collided and 2018 comedy Banana Split, although he’s also been focused on running his own mead-making factory in Brooklyn, New York.
His brother Cole Sprouse is a star on hit TV drama Riverdale.