The actress, who is enjoying critical success with new movie The Kids Are All Right, will be presented with the accolade at a ceremony on 28 January (11), during the 26th edition of the film festival.
The American Riviera Award was established to recognise an actor/actress who has had a strong influence on American cinema.
Past recipients have included Mickey Rourke, Tommy Lee Jones, Forest Whitaker, Philip Seymour Hoffman and Kevin Bacon.
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Sandra Bullock was honoured in February (10), while Diane Lane received the prize in 2004.
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