The youngest daughter of a performing family including brother David Arquette and sister Rosanna Arquette, vivacious and vulnerable Patricia Arquette rose through the 1990s independent film world to become a leading player for directors like Tim Burton, David Lynch and Sean Penn. Her breakthrough role in Tony Scott's crime spree "True Romance" (1993) led to more risky but stylish fare, including "Lost Highway" (1997) and "Stigmata" (1999), but the actress also proved her widespread appeal with mainstream dramas like Martin Scorsese's "Bringing Out the Dead" (1999) and comedies like "Little Nicky" (2000). The actress also endured a tabloid fascination with her love life after dating Christian Slater and marrying and divorcing Nicholas Cage. In 2005, Arquette made an unlikely leap to series television with resounding success, due to her portrayal of a hectic working mom who also happens to be a gifted psychic on the long-running procedural, "Medium" (NBC/CBS, 2005-2011), which earned the actress an Emmy Award, as well as mainstream success. Though she appeared in only one film during her seven seasons on "Medium," Arquette was poised for a big screen comeback once "Medium" finally ended, and ended up winning a Best Supporting Actress Oscar for her work on Richard Linklater's unique family drama "Boyhood" (2014).