The moviemaker's 2009 comedy, starring Helms alongside Bradley Cooper, Zach Galifianakis, Justin Bartha and Heather Graham, was a critical and commercial success, making a massive $467 million (£311 million) at the worldwide box office and winning a Golden Globe award for Best Picture - Musical or Comedy.
The cast is currently filming a follow-up, which will see the characters travel to Thailand for a wedding, but Helms is adamant they won't be reprising their roles a third time.
When asked about the possibility of another sequel, he tells the Los Angeles Times, "I doubt it. I don't think Todd would let that happen... I would hope that The Hangover kind of has a dignified legacy, if that makes any sense."